The lipoprotein lipase S447X polymorphism and plasma lipids
نویسندگان
چکیده
منابع مشابه
The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption.
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and 2) to explore any interactions with apolipoprotein E (APOE) genotype, exercise, obesity, cigarette smoking, and alcohol intake. Information on...
متن کاملThe S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids.
OBJECTIVE The objective of this study was to evaluate the effect of polymorphism S447X on plasma lipids of patients with premature coronary artery disease (CAD). METHODS Plasma lipids and genotypes were determined in 2 groups: 313 patients with premature CAD (<55 years of age) and 150 controls without CAD. RESULTS Frequency of the S447X polymorphism was 18% in patients with CAD and 23% in t...
متن کاملAssociation between Lipoprotein Lipase Hind III Polymorphism and Serum Levels of Lipids in Semnan City
Background & Aims: Lipoprotein lipase (LPL) is one of the key enzymes regulating the metabolism of triglycerides (TG) and HDL cholesterol. The lipoprotein lipase (LPL) gene polymorphisms are possibly involved in the pathophysiology of dyslipidemia. Hind III polymorphism is one of the most common polymorphisms in LPL gene. In some studies, association of Hind III polymorphism with dyslipidemia h...
متن کاملGene therapy with lipoprotein lipase variant S447X.
Variant S447X To the Editor: Ross et al recently reported a dazzling series of in vivo experiments1 showing reversal of abnormal biochemical phenotypes in Lpl / mice through adenoviral-mediated gene transfer of the socalled “gain-of-function” S447X prematurely truncated human variant of lipoprotein lipase (LPL or LIPD). Furthermore, all readouts in lipase-deficient mice treated with this human ...
متن کاملS447X Polymorphism in the Lipoprotein Lipase Gene and the Adiponectin Level in the General Population S447X Polymorphism in the Lipoprotein Lipase Gene and the Adiponectin Level in the General Population: Results from the Mima Study
Aim: Lipoprotein lipase (LPL) plays an important role in lipid metabolism. There is an association between the common S447X polymorphism in the LPL gene and high-density lipoprotein cholesterol (HDL-C) levels, and some association between circulating HDL-C and adiponectin levels has been suggested; however, it is not known whether there is any association between the S447X polymorphism and adip...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2004
ISSN: 0022-2275
DOI: 10.1194/jlr.m400016-jlr200